Stay on the safe side and avoid use. Black seed might slow blood clotting. 2003;39:365-370. Early research shows that taking black seed ass part of the diet while undergoing cancer drug treatment might prevent fever episodes due to low white blood cell counts (neutropenia) in children. Toxicol Lett 1998;95:23-9. A skin disorder that causes white patches to develop on the skin (vitiligo). Biomed.Sci Instrum. 1996;35(7):493-497. Ann.Saudi Med 2001;21(3-4):242-244. Mansour, M. A. In ancient texts and historical documents black cumin seed is noted for its therapeutic attributes and ability to support the body in its own natural healing processes. View abstract. Black seed oil is a common supplement used in alternative medicine to help treat a variety of conditions. View abstract. Int J Cancer 11-10-2005;117(3):409-417. Yi, T., Cho, S. G., Yi, Z., Pang, X., Rodriguez, M., Wang, Y., Sethi, G., Aggarwal, B. Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Journal of Medicine (EAST J MED) 2004;9(1):4-6. View abstract. Ghannadi, A., Hajhashemi, V., and Jafarabadi, H. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, Fias. Anat.Rec.A Discov.Mol.Cell Evol.Biol. 2020. Zaoui, A., Cherrah, Y., Alaoui, K., Mahassine, N., Amarouch, H., and Hassar, M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. El Gouhary, I., Mohamed, A., Suleiman, S., and Benghuzzi, H. Comparison of the amelioration effects of two enzyme inducers on the inflammatory process of experimental allergic encephalitis (EAE) using immunohistochemical technique. Infection of the throat and tonsils (tonsillopharyngitis). Med Sci Monit. Ozbek, H. Determination of lethal doses of volatile and fixed oils of several plants. View abstract. View abstract. Al Shabanah, O. Erdurmus, M., Yagci, R., Yilmaz, B., Hepsen, I. F., Turkmen, C., Aydin, B., and Karadag, R. Inhibitory effects of topical thymoquinone on corneal neovascularization. The black seed of nigella sativa (black cumin seed) has been used for over three thousand years for preventing and treating many different diseases. Curr.Clin Pharmacol. View abstract. View abstract. View abstract. 2005;28(2):301-305. View abstract. 2005;41:376-381. 2. Kruk, I., Michalska, T., Lichszteld, K., Kladna, A., and Aboul-Enein, H. Y. Zhongguo Zhong.Yao Za Zhi. View abstract. Food Chem.Toxicol. Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. 2003;22(1):107-113. Pak.J Pharm Sci. The seeds can also flavor curries, pickles, and bread in a similar way to cumin or oregano. People use it to treat digestive ailments and respiratory problems, but studies have shown it also has cancer fighting agents. Res Vet.Sci 2004;77(2):123-129. Phytother Res. Taking black seed while being treated for a type of leukemia called acute lymphoblastic leukemia might increase the chances of staying cancer-free once treatment ends. 2003;11:104-110. View abstract. Medenica RD. 2010;32(1):126-131. Res Vet.Sci 2004;77(2):123-129. View abstract. Landa, P., Marsik, P., Havlik, J., Kloucek, P., Vanek, T., and Kokoska, L. Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species. 2009;47(11):2768-2775. Antitumour principles from Black seed seeds. Kanter, M., Coskun, O., Korkmaz, A., and Oter, S. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. br/> Life Sci 12-16-2009;85(23-26):830-834. Biomed.Sci Instrum. Type 2 diabetes – Researchers found that just two grams daily of black seed could result in reduced fasting blood sugar levels, along with decreased insulin resistance, and increased beta-cell function in the pancreas. 2002;46(2):195-201. View abstract. Najmi, A., Nasiruddin, M., Khan, R. A., and Haque, S. F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. 7-30-2009;124(3):416-420. Childs Nerv Syst. 2009;59(6):363-368. Hajhashemi, V., Ghannadi, A., and Jafarabadi, H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Free Radic.Res 2007;41(2):153-161. View abstract. Planta Med 2002;68(5):465-466. El Mahmoudy, A., Shimizu, Y., Shiina, T., Matsuyama, H., Nikami, H., and Takewaki, T. Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone. Black seed might lower blood sugar in some people. View abstract. View abstract. Gazi Univ.Eczacilik Fak.Derg. View abstract. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Effect of thymoquinone on ethylene glycol-induced kidney calculi in rats. World J Gastroenterol. View abstract. 2007;37(3):801-813. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Richards, L. R., Jones, P., Hughes, J., Benghuzzi, H., and Tucci, M. LNCaP cells exposed to ceramic drug delivery treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid. View abstract. Keyhanmanesh, R., Boskabady, M. H., Eslamizadeh, M. J., Khamneh, S., and Ebrahimi, M. A. Planta Med 1995;61:33-6. View abstract. View abstract. Sangi, S., Ahmed, S. P., Channa, M. A., Ashfaq, M., and Mastoi, S. M. A new and novel treatment of opioid dependence: Nigella sativa 500 mg. J Ayub.Med Coll.Abbottabad. Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR. 1-30-2009;121(3):419-424. View abstract. View abstract. 2009;7(1):9. A., Ali, B. View abstract. Inhibitory effect of Nigella sativa on histamine receptors of isolated guinea pig tracheal chains. Dtsch.Tierarztl.Wochenschr. The following doses have been studied in scientific research: View abstract. [Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera]. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. 9-7-2008;14(33):5204-5209. J Infect.Chemother. 2007;13(12):CR555-CR559. Chemosphere 2000;41(7):1059-1064. Cell Biochem.Funct. View abstract. View abstract. El-Gharieb MA and et al. He T, Xu X. Bourgou, S., Ksouri, R., Bellila, A., Skandrani, I., Falleh, H., and Marzouk, B. Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. Gali-Muhtasib, H., Diab-Assaf, M., Boltze, C., Al Hmaira, J., Hartig, R., Roessner, A., and Schneider-Stock, R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Biol.Trace Elem.Res 2007;115(2):157-167. Oshchepkova, IuI, Veshkurova, O. N., Rogozhin, E. A., Musoliamov, A. K., Smirnov, A. N., Odintsova, T. I., Egorov, TsA, Grishin, E. V., and Salikhov, ShI. Aggarwal, B. Sathisha, U. V., Jayaram, S., Harish Nayaka, M. A., and Dharmesh, S. M. Inhibition of galectin-3 mediated cellular interactions by pectic polysaccharides from dietary sources. Gynecol Endocrinol. 1-24-2009;131(3):e115-e117. Salama, R. B. Sterols in the seed oil of Nigella sativa. View abstract. Black cumin seed benefits range from cancer prevention, all the way to diabetes management. View abstract. A., Tan, M., May, M., Tucci, M., and Benghuzzi, H. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. 1965;48:Suppl-202. View abstract. High blood pressure. 2010;92(2):395-412. Morikawa, T., Xu, F., Kashima, Y., Matsuda, H., Ninomiya, K., and Yoshikawa, M. Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Alive: Canadian Journal of Health & Nutrition. Here are some of the benefits of black seed: • Increases milk supply for nursing mothers • Expels kidney stones 2010;25(2-3):307-314. Amara, A. B. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. Nickavar, B., Mojab, F., Javidnia, K., and Amoli, M. A. Hansen, J. T., Benghuzzi, H., Tucci, M., and Cason, Z. Kanter, M., Meral, I., Dede, S., Gunduz, H., Cemek, M., Ozbek, H., and Uygan, I. It's unknown if black seed improves memory and thinking skills in girls and women. Benhaddou-Andaloussi A and et al. 2008;52(2):141-148. Beauty. View abstract. Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Studies on the antimicrobial activity of Black seed seed (black cumin). Ragheb, A., Attia, A., Eldin, W. S., Elbarbry, F., Gazarin, S., and Shoker, A. 2002;79(1):23-26. Cell Mol.Biol. Salih, B., Sipahi, T., and Donmez, E. O. Yakugaku Zasshi 2006;126(4):301-305. Biomedicine (Taipei) 2019;9(3):20. Health Benefits of Black Seed 1. View abstract. View abstract. View abstract. View abstract. This survey is being conducted by the WebMD marketing sciences department. Ali, Z., Ferreira, D., Carvalho, P., Avery, M. A., and Khan, I. Kanter, M., Coskun, O., and Uysal, H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Landa, P., Marsik, P., Havlik, J., Kloucek, P., Vanek, T., and Kokoska, L. Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species. Afr J Tradit Complement Altern Med. Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic beta-cells, skeletal muscle cells, and adipocytes. View abstract. View abstract. B., and Malone, M. H. Studies on the antihistaminic effects of thymoquinone, thymohydroquinone and quercetin. Early research shows that black seed helps with some but not all measures of memory and attention in boys and men. View abstract. View abstract. View abstract. Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Agrawala, I. P., Achar, M. V., and Tamankar, B. P. Galactogogue action of Nigella sativa. Fundam.Clin Pharmacol. Kumara, S. S. and Huat, B. T. Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa. View abstract. Amin, K. A. and Nagy, M. A. Early research shows that applying a cream containing black seed oil to the skin for 6 months can improve skin color in some people with vitiligo. Salarinia R, Rakhshandeh H, Oliaee D, Gul Ghasemi S, Ghorbani A. The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis. Jadayil, S. A., Tukan, S. K., and Takruri, H. R. Bioavailability of iron from four different local food plants in Jordan. The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial. Biomed.Sci Instrum. 2004;18(5):395-398. View abstract. Avicenna J Phytomed. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Pak Med Assoc 1991;41:185-7. View abstract. A., and Al Sawaf, H. A. Can J Physiol Pharmacol. Urol.J 2008;5(3):149-155. Abbas, A. T., Abdel-Aziz, M. M., Zalata, K. R., and Tel, Abd Al-Galel. 2006;42:363-371. Salomi NJ, Nair SC, Jayawardhanan KK, et al. Arzneimittelforschung. Arch Toxicol. Effectiveness of topical Nigella sativa seed oil in the treatment of cyclic mastalgia: A randomized, triple-blind, active, and placebo-controlled clinical trial. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. A., Jyothy, A., and Lei, D. K. Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Kamal EH and et al. 1999;19(5):757-762. View abstract. Herba Polonica (Poland) 2007;53:279-285. 11-14-2005;11(42):6662-6666. Kanter, M., Meral, I., Yener, Z., Ozbek, H., and Demir, H. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. 2009;40(2):107-115. It has minimal (if any) side effects and adds important nutrients to the diet. View abstract. Behnamfar N, Parsa Yekta Z, Mojab F, Kazem Naeini SM. Benhaddou-Andaloussi, A., Martineau, L. C., Vallerand, D., Haddad, Y., Afshar, A., Settaf, A., and Haddad, P. S. Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. Some people apply black seed directly to the skin for joint pain (rheumatism), headache, and certain skin conditions. Nephrol.Dial.Transplant. View abstract. View abstract. Hanafy MS, Hatem ME. Biochem.Pharmacol. The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice. Phytochemistry 2009;70(4):517-522. Asgari S and et al. 2007;43:242-247. Gali-Muhtasib, H., Ocker, M., Kuester, D., Krueger, S., El Hajj, Z., Diestel, A., Evert, M., El Najjar, N., Peters, B., Jurjus, A., Roessner, A., and Schneider-Stock, R. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. 2007;43:272-277. Food Chem.Toxicol. Kanter, M. Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations. 2003;85(1):7-14. Research shows that taking black seed by mouth along with asthma medicines can improve coughing, wheezing, and lung function in some people with asthma. J Ethnopharmacol. Taking black seed along with medications used for lowering high blood pressure might cause your blood pressure to go too low. Geng, D., Zhang, S., and Lan, J. Dirjomuljono, M., Kristyono, I., Tjandrawinata, R. R., and Nofiarny, D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. J Hypertens 2016;34:2127-35. Le, P. M., Benhaddou-Andaloussi, A., Elimadi, A., Settaf, A., Cherrah, Y., and Haddad, P. S. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. Phytother.Res. A. Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. 2015;6(6):2041-8. Ibrahim, Z. S., Ishizuka, M., Soliman, M., ElBohi, K., Sobhy, W., Muzandu, K., Elkattawy, A. M., Sakamoto, K. Q., and Fujita, S. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Hay fever. Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. J Ethnopharmacol 2018;219:173-81. doi: 10.1016/j.jep.2018.03.001. View abstract. B., Harikumar, K. B., Tharakan, S. T., Sung, B., and Anand, P. Potential of spice-derived phytochemicals for cancer prevention. Int J Cardiol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Carbohydr.Res 1-5-2009;344(1):149-151. Finlay, T. M., Jayanth, P., Amith, S. R., Gilmour, A., Guzzo, C., Gee, K., Beyaert, R., and Szewczuk, M. R. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. View abstract. Chem.Pharm.Bull (Tokyo) 2004;52(4):494-497. Yildiz, F., Coban, S., Terzi, A., Ates, M., Aksoy, N., Cakir, H., Ocak, A. R., and Bitiren, M. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. Jadayil, S. A., Tukan, S. K., and Takruri, H. R. Bioavailability of iron from four different local food plants in Jordan. A. and Morcos, M. Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells. Chehl, N., Chipitsyna, G., Gong, Q., Yeo, C. J., and Arafat, H. A. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. View abstract. 2001;108(2):71-73. 2020;31(1):21-31. View abstract. Farah, N., Benghuzzi, H., Tucci, M., and Cason, Z. View abstract. 2006;12(2):100-104. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. crude seed oils and oil fractions. Pharmaceutical Biology (Netherlands). Int J Oncol. 2015 Mar;28(2):493-8. View abstract. View abstract. View abstract. ChemMedChem. Ren Fail. A. and Gamal el-Din, A. M. Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. A., and Bamosa, A. O. 2018;38:48-57. View abstract. Haq A, Abdullatif M, Lobo PI, et al. View abstract. essential oils and their major constituents, thymoquinone and beta-elemene. Planta Med 2004;70(12):1243-1246. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Early research shows that applying black seed oil around the area where cancer drugs are injected into a vein might prevent swelling of that vein. Badary OA, Al-Shabanah OA, Nagi MN, et al. View abstract. Bamosa, A. O., Ali, B. Commun.Agric.Appl.Biol.Sci 2005;70(4):601-611. Kanter, M., Akpolat, M., and Aktas, C. Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. View abstract. View abstract. Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial. 2006;38(8):1249-1253. Toama, M. A., El Alfy, T. S., and El Fatatry, H. M. Antimicrobial activity of the volatile oil of Nigella sativa Linneaus seeds. There are now over 650 peer-reviewed studies that have looked into the health benefits of black seed. B., and Liu, M. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. View abstract. View abstract. Eur.J Pharmacol. Pharmaceutical Biology (Netherlands). View abstract. Saudi Pharmaceutical Journal (Saudi Arabia). Badary OA, Al-Shabanah OA, Nagi MN, et al. al Sheikh, O. 2-25-2004;4:3. View abstract. View abstract. Akhtar MS, Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. Neuropharmacology 2005;49(4):456-464. Iddamaldeniya, S. S., Thabrew, M. I., Wickramasinghe, S. M., Ratnatunge, N., and Thammitiyagodage, M. G. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Transl Med 2014;12:82. View abstract. J Ethnopharmacol. Historically, black seed has been used for headache, toothache, nasal congestion, and intestinal worms.It has also been used for “pink eye” (conjunctivitis), pockets of infection (abscesses), and parasites. Boskabady MH and et al. Early research shows that taking black seed oil might prevent heart damage in children being treated with a drug called doxorubicin. 2003;39:371-376. J Agric.Food Chem. Med Sci Monit. J Ethnopharmacol 1991;31:283-9. 2006;80(4):217-224. Planta Med 2001;67(1):29-32. A., and Khalifa, A. View abstract. View abstract. Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FBI. View abstract. Indian J Physiol Pharmacol. The effect of Nigella sativa L. supplementation on serum C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. View abstract. 2009;47:77-80. View abstract. The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. Comparative study of nigella sativa and triple therapy in eradication of helicobacter pylori in patients with non-ulcer dyspepsia. Khan, N. and Sultana, S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Vahdati-Mashhadian, N., Rakhshandeh, H., and Omidi, A. View abstract. Eur.J Cardiothorac.Surg. 2005;5(1):195-207. A., Alhaider, A. The powder delivers soothing benefits and is easily digestible. View abstract. View abstract. A., Ali, B. Erratum in: Biomedicine (Taipei) 2019;9(4):30. 2018 Dec;68(12):696-703. Children: Black seed oil is POSSIBLY SAFE for children when taken by mouth short-term and in recommended amounts. View abstract. 2013 Apr 28;19(16):2529-36. Badary, O. Studies are generally small and low-quality, so more research is needed. 8-14-2006;543(1-3):40-47. View abstract. Biomed.Sci.Instrum. [Isolation of the lipid-transporting protein Ns-LTP1 from seeds of the garden fennel flower (Nigella sativa)]. Immunopharmacology 1995;30:147-55. Hadjzadeh, M. A., Mohammadian, N., Rahmani, Z., and Rassouli, F. B. View abstract. 2003;84(2-3):251-258. A., and Al Khalaf, M. I. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. View abstract. It was even discovered in the tomb of King Tut. View abstract. Black seed oil in combination with olive oil, calamus, and henna leaves provide a soothing effect in the case of a burn. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. Hosseinzadeh, H. and Parvardeh, S. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. el Dakhakhny, M., Mady, N., Lembert, N., and Ammon, H. P. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Al Hariri, M. T., Yar, T., Bamosa, A. O., and El Bahai, M. N. Effects of two-months Nigella sativa supplementation on cardiac hemodynamics and adrenergic responsiveness. Plant Foods Hum.Nutr. Effect of different levels of feed added black seed (Nigella sativa L.) on the performance of broiler chicks. Nagi, M. N. and Almakki, H. A. Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Black seed might increase the immune system. Fallah Huseini H, Amini M, Mohtashami R, et al. 2013;148(3):780-6. Int J Dermatol. Landa, P., Kokoska, L., Pribylova, M., Vanek, T., and Marsik, P. In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis. Evaluation of safety and efficacy profile of Nigella sativa oil as an add-on therapy, in addition to alpha-keto analogue of essential amino acids in patients with chronic kidney disease. 2002;20(2):143-151. What factors influenced or will influence your purchase? 2004;279(1):685-691. Kacem, R. and Meraihi, Z. specific immunotherapy in allergic rhinitis patients. View abstract. View abstract. 2008;20(2):118-124. J Ethnopharmacol. AAPS.PharmSciTech. Pari, L. and Sankaranarayanan, C. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Indian J Exp.Biol. Neurochem.Res 2008;33(3):579-588. Res Vet.Sci 2010;88(3):400-404. Dermatol Ther 2019;32(4):e12949. View abstract. J Ayub.Med Coll.Abbottabad. 2007;21(9):895-897. Studies on the activity of individual plants of an antidiabetic plant mixture. Mousavi, S. H., Tayarani-Najaran, Z., Asghari, M., and Sadeghnia, H. R. Protective Effect of Nigella sativa Extract and Thymoquinone on Serum/Glucose Deprivation-Induced PC12 Cells Death. It was even discovered in the tomb of King Tut. J Altern.Complement Med 2008;14(9):1137-1144. Ali, B. H. The effect of Nigella sativa oil on gentamicin nephrotoxicity in rats. Breyer, S., Effenberger, K., and Schobert, R. Effects of thymoquinone-fatty acid conjugates on cancer cells. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. Biomed.Sci Instrum. Early research shows that taking black seed oil might help to improve kidney function in these people. 2006;13(5):324-333. High levels of cholesterol in people being treated for breast cancer cells, oil... W, Theoharides TC O., and hemorrhoids consult a doctor before black. 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